A wealthy judge coaxes the brilliant but eccentric neurological surgeon Dr. Vollin (Lugosi), who also has an obsessive penchant for Edgar Allen Poe, out of retirement to save the life of his daughter, a dancer crippled and brain damaged in an auto wreck. Vollin restores her completely, but also envisions her as his "Lenore," and cooks up a scheme to kidnap the woman and torture and kill her fiance’ and father in his Poe-inspired dungeon. To do his dirty work, Vollin recruits a wanted criminal (Karloff), and turns him into a hideous monster to guarantee his subservience.
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